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Bayern are already without winger Serge Gnabry, who suffered a hamstring knock on his return to the Emirates.
And they will also miss left-back Alphonso Davies against Mikel Arteta’s men due to suspension following his yellow card in north London.
Tuchel could now see French forward Coman set for a spell on the sidelines after he went off in the second half during Saturday’s 2-0 home win over Cologne.
The 27-year-old appeared to pick up a knee problem, leading to him being replaced by Jamal Musiala shortly after the break.
He hobbled off the pitch where he had to be supported by Bayern medics either side of him.
Bayern had even omitted Leroy Sane from their squad to face Cologne, with Tuchel keen to maintain his fitness.
It was the same situation for goalkeeper Manuel Neuer, with the pair only returning from injury midweek in the European Cup.
Should Coman be ruled out against Arsenal, it is likely that Musiala and Sane will be deployed on the wings, with Harry Kane leading the line.
Coman came off the bench against Arsenal where he almost won it late on for the visitors.
He got in front of his marker at the near post to meet Musiala’s low cross, but could only guide his flicked effort onto the woodwork.
